‘Hustle’ is a contemporary/hip hop term that taken literally, means doing something illegal to make money, including but not limited to laundering money, selling drugs, and ‘popping a cap in someone’s ass’ to steal from them. The word has now evolved to become more of an all purpose term meaning to do things to get closer to your personal aim. It suggests an entrepreneurial type job or service.
Another variation is ‘E-hustle’ which according to it's definition here on Urban Dictionary means: "Aggressive entrepreneurial pursuit; moving, shaking, sharing, selling, promoting, using the web as the platform for diverse forms of commerce and communication while maintaining social responsibility."
'Bless My Hustle' then is quite literally a plea for blessing on one's journey to success.
2. I'm going to pull an all-nighter to finish this paper. Bless my hustle.