An extreme version of the trashy connotation of ghetto
, derived from pseudo-Afrocentric names usually involving "qu" (e.g. ShaQuanda, LaQuisha, Quanisha).
Look at that blue weave and those six inch airbrushed nails... That girl is ghettwo.
Your TV is sitting on a cooler with a pair of Prada shoes laying in front of it on the carpet you do not vacuum, but sweep with a broom. Your house is ghettwo.