As one example, you may use this acronym on YouTube when your video contains an audio (sound) component that some viewers may find distasteful, such as heavy metal music like Anthrax or Megadeth.
*NSFYE* (Not Safe For Your Ears). A video of the Syma S107G R/C Coaxial Helicopter flying in my room, set to another Anthrax song.
Abort this video immediately if you find thrash metal music distasteful.
That music you hear is the song "Howling Furies" by Anthrax. This heli is not sound-sensitive; the audio may safely be ignored or even muted if it pisses you off.