Sheldon Cooper is one of the main characters of the TV-show The Big Bang Theory. He is extremely intelligent, but due to what appears to be Asperger's Syndrome, he is incapable of understanding other people and sarcasm. That said, he is probably the most hilarious character on TV right now. Although he would probalby look upon the tomfoolery of the show with haughty derision.
Leonard: How was Nebraska?
Penny: Oh, better than North Dakota.
Penny: Guess that joke's only funny in Nebraska.
Sheldon Cooper: With the data at hand, you really can't draw that conclusion. All you can say with absolute certainty is that joke is not funny here.