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1.
Soul: the immaterial part of a person; the actuating cause of an individual life

Sister: a female person who has the same parents as another person

Soul Sister: Someone who fully understands you. Like a soulmate, but not someone you want to marry and make babies with. The sister of your soul.
1)As quoted in Confessions of a Teenage Drama Queen, "Ella Gerard you are the sister of my soul"

2)Hayley just gets me, she understand everything about me, she's my soul sister.
автор: teenagedramaqueen 9 апреля 2006
 
2.
The female equivalent of a blood brother. A best friend of the female persuasion that you consider family. Most times, the feeling is mutual.
Jackie and Rachel are soul sisters. It's like they have the same mother!
автор: wolfpacleader1986 8 октября 2010
 
3.
Two or more females who click on every level imaginable; who can talk about EVERYTHING from gorgeous foreign boys (or lack there of) to existentialism. Who reminisce, learn, dance, sing, complain, celebrate, play and dream together. Who will forever believe that they were born together and somehow separated at birth only to be brought together by fate at a later date in their lives. Where small talk doesn't exist and it's all about BIG talk. Soulsisters are forever yin and yang. From the very first breath to the very last.
Sucks-for-you, Bianca's MY soulsister.

:]
автор: Sarah Martin 16 января 2005
 
4.
A referent for a Black female. Since at least the early 2000s "soul sister" is usually shortened to sista without the word "soul". "Soul brother" brotha is the equivalent referent for a Black male.
1.Soul sister #9, sock it to me one more tme.

2. That soul sister knows she's lookin good.
автор: azizip17 21 декабря 2011
 
5.
boy or girl; someone of the opposite sex who you have everything in common with from music taste to birth defects. Even if you don't speak to this person frequently, when you do you can become like siblings within the hour.
Girl #1: "We have the same favorite song! Our parents have the same name! We both are allergic to Heinz Ketchup!"
Girl #2 "Why don't you marry him then?"

Girl #1: "I would, but we're already soul sisters!"
автор: truth goat 4 июня 2014