A Bastardization of 'werk' which is a bastardization of 'work'. Twirk is mainly used to talk about strippers, or women in sexually scandalous professions doing work. It can also be used as simply saying: "Twirk" that ass ( Work that ass )
Twirk fo' a dub dough
Twirk it real hard
Ya gotta twirk a lil harder!
My hoes be twirkin it all night to bring me the cash flow.