However, despite the serious carcinogenic and mutagenic effects of nicotine, there is a more serious, immediate side-effect seen of this performance society induced self-treatment, eg AEDS. AEDS is the effect one experiences after just one or 2 doses caffein and not more than 5 doses of nicotine. The result is an explosive diarrhea accompanied by severe stomach-cramps and possibly bleeding of the anus and rupture of the intestinal lamina as well as dehydration and light-headedness. Leading to hemarroids, internal bleeding, and possibly death due to severe immune-responses.
It can even be said, without caution using these drugs, AEDS is the chemical equivalent of cholera.
Hence, the author of this article advises caution when using this treatment during the first hours of the day.