Different from disrespect.
When a person looses all or major respect for someone and/or starts to unlike that person.
girl 2. i know right, did you hear she may to pose for playboy? what a slore
guy1. yeah, shes hot though
girl 1. wow i just lost all respect for you
girl 2. me too i de-respect you now
i use to like heartless from kanye but after the VMAs i de-respected him.