It means for sure ma brother
dude- so you wanna go hang with shaleesha and shaquinta
brotha- Fo SHizzle My Nizzle
2. To informally aquiesce or agree with someone whom you consider an affable peer.
It was a chant that the greek soldiers on the aegean islands were shouting when they were defending them against the Turks.
-fo shizzle my nizzle.