"Yo, do you wanna grab some fresh tonight?" (referring to purchasing cocaine)
"Let's freshen up, bro!" *thumps chest*
"I can't wait to get fresh, I'm fiending like a motherfucker!" *thumps chest*
2. another way of saying "yo thats tight"
3. slick, sly, trying to put the moves on, hitting on..etc.
2. o! i got to admit dats pretty fresh still
3. don't try to get all fresh nd wat with me, anthony. better keep your hands to yourself and keep it in your pants! damn yo i aint feeling u like dat! we just friends, aight? cool