a highfive with two unisex people where both partake in a hopelessly awkward gesture. The awkward gesture is linked to the same reaction when you are unaware of the sex of a person. Another form of the gesture is the reaction to walking in on your mother giving head to your father. Even better yet using glue instead of lubricant when masturbating, only to find you have to call your best friend to take you to the hospital. Other variations are less common, however they maybe used.
Bret: "I bought you pants that say 'Enter Here' with an arrow pointing to your ass"
Bret: "Genderless highfive"
Rico: "Wait what?"
Rico: "Oh shit"
Rico: "I heard that wrong."