A: What's a hot tomale?
B: I donno. Do you mean tamale?
A: Oh... yeah, I guess.
B: Well, a tamale is a Mexican food made of cornmeal & lard, with typically a pork filling. A "hot tamale" can be a spicy cinnamon candy. Or it could be a reference to someone appealing to the eye.
A: Man I'm a dumbass.
B: I know.
For full effect, couple this with a Dirty Sanchez for the ultimate "South of the Border" experience.
Person 2: Yeah, he gave her the Hot Tomale!
Person 1: Bet that's the last time she ever wants Mexican food.