"So remember, my friends, if you’re going to rinse and repeat always beware the extra bubbles." -- From the movie "The Lather Effect"
The effect of not being able to get drunk because of a high-state of trashedness the night before.
If you have been highly wasted one night, and try to get inebriated the next night it will cost you a fortune because it's nearly impossible.
The term comes from trying to lather a loufah, but it will not lather if there is still soap in it from the day before.
Dude 1: "You've had like 7 drinks and you're still a freakin intellect"
Dude 2: "Lather Effect, I had a crazy night last night."