1. To tell someone new or uninformed how to survive in their environment who to respect who to get over on and over all how to win. (typically relating to the drug game or pimp game.)
2. to tell you how it is and how it will be.
"let me put you up on game homie before you get your head took off by these cats." Typically used as westcoast terminology.
The Game used this phrase as a hook for one of his songs.