2. The madness you get not from smoking marijuana, but the lack there of in your system on a daily basis.
2. Dude, it's been three days since I've puffed. I've got reefer madness!!!
Today it's a humurous description used by pot-heads to describe the stigma and false beliefs believed and enforced by the uneducated and ignorant to marijuana.
2. I'm going to get a bad case of reefer madness, because timmy ate all my reefer brownies.
3. Jim wants my reefer but it's already gone, I hope he goes mad!