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1.
the generic name for a date rape drug
Hey i slipped Anna ruffies this weekend.
автор: blackdahlia 19 февраля 2004
 
2.
A bocce throw, when the ball is thrown overhand as hard as possible to know the other teams ball away from the palino. The name Ruffe stems from the generic date rape drug name, and with both the date rape drug, and this throw, the main purpose is to knock out the target.
"Go for a Ruffe so they dont score their ninth point and win this round."
автор: Bocceman 25 сентября 2009
 
3.
Something someone slips into a girl's drink so he can have sex with her
Peter wants to slip a ruffe into Tara's drink so he can have sex with her.
автор: Paul 30 марта 2005