On futurama, when Fry, pulled one of the lanterns from the old church, ruining Paul Revere's midnight ride; Professor Farnsworth informed him of his screwup of historical proportions by saying: "Fry, you dope! You've really screwed the granny this time.".
"You read from the Necronomicon and unleash Lord Cthulhu on Australia?! Well, it looks like you've really screwed the granny on this one."
Marty McFly, you kissed your mom?!? Boy, you've really screwed the granny this time!